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Lipid peroxidation impairs motility by decreasing membrane fluidity

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Nonetheless, the high cost of producing gluconeogenic substrate from protein catabolism underscores the importance of the ensuing shift away from glucose-centric metabolism as reflected by a decline in the Respiratory Quotient (an indicator of macronutrient catabolism on indirect calorimetry), and accounting for the relatively short duration of the phase in which glucose is a dominant systemic fuel source (32)